Zardaverine

SIGMA/Z3003 - phosphodiesterase inhibitor

Synonym: 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

CAS Number: 101975-10-4
Empirical Formula (Hill Notation): C₁₂H₁₀F₂N₂O₃
Molecular Weight: 268.22
MDL Number: MFCD00867059
Linear Formula: C₁₂H₁₀F₂N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-Z3003-5MG	5 mg	$184.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChI key	HJMQDJPMQIHLPB-UHFFFAOYSA-N
potency	1.1 μM IC₅₀ (for PDE IV)
	2.5 μM IC₅₀ (for PDE III)
Quality Level	200
SMILES string	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

Application:	Zardaverine has been used as a phosphodiesterase inhibitor: • to study its effects on human colonic epithelial cells • to study its effects on junctional proteins in Sertoli cells • to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells
Biochem/physiol Actions:	Selective inhibitor of phosphodiesterase III/IV (PDE3/4).
Biochem/physiol Actions:	Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
UNSPSC	12352202

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