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ZD7288 hydrate

SIGMA/Z3777 - ≥98% (HPLC)

Synonym: 4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride; ICI-D7288; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine hydrochloride; ZD 7288

Empirical Formula (Hill Notation): C15H20N4 · HCl · xH2O
Molecular Weight: 292.81 (anhydrous basis)
MDL Number: MFCD16879001
Linear Formula: C15H20N4 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Z3777-5MG 5 mg
 $142.00
1/EA		 Add To Favorites
45-Z3777-25MG 25 mg
 $557.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H20N4.ClH.H2O/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;;/h6-11H,5H2,1-4H3;1H;1H2/b16-14+;;
InChI key NCEDDDWQLCMZQG-UPONXUSQSA-N
originator AstraZeneca
Quality Level 100 
SMILES string O.Cl.CCN(c1ccccc1)C2=CC(=N/C)N(C)C(C)=N2
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: ZD7288 hydrate has been used as Ih blocker to study its effect on
neocortical tissue. It has been used as hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker to test the involvement of HCN channels in the phototransduction pathway.
Biochem/physiol Actions: Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.
Biochem/physiol Actions: ZD7288 can block hippocampal synaptic plasticity.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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