Zerumbone
SIGMA/Z3902 - ≥98% (HPLC)
Synonym: (2E,6E,10E)
CAS Number: 471-05-6
Empirical Formula (Hill Notation): C15H22O
Molecular Weight: 218.33
MDL Number: MFCD03700769
Linear Formula: C15H22O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C15H22O/c1-12-6-5-7-13 |
| InChI key | GIHNTRQPEMKFKO-SKTNYSRSSA |
| Quality Level | 100  |
| SMILES string | CC1=C/CC(C)(C)C=CC(=O) |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | 2-8°C |
| Application: | Zerumbone has been used: • for liquid chromatography with mass spectrometry (LC-MS-MS) • to investigate its potential application in the prevention • treatment of esophageal squamous cell carcinomas (ESCC) |
| Biochem/physiol Actions: | Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger). |
| General description: | Zerumbone is a monocyclic sesquiterpene compound, which is extracted from the essential oil of Zingiber zerumbet rhizomes. It has antimicrobial, antinociceptive, antiatherosclerotic, hepatoprotective and antioxidant properties. Zerumbone also has anti-inflammatory and anticancer effects. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317 - H400 |
| Precautionary statements | P273 - P280 - P302 + P352 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |