Zymosan A from Saccharomyces cerevisiae
SIGMA/Z4250 - for inducing inflamatory response
Synonym: Yeast Cell Wall
CAS Number: 58856-93-2
MDL Number: MFCD00082157
Product Type: Chemical
| biological source | Saccharomyces cerevisiae |
| color | off-white to light brown |
| form | powder with small lumps |
| Quality Level | 200  |
| storage temp. | 2-8°C |
| technique(s) | flow cytometry: suitable |
| tissue culture: suitable |
| Application: | • in flow cytometry • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss) |
| Application: | Zymosan A from Saccharomyces cerevisiae has been used: • as a positive control to determine the activation of complement cascade • for respiratory burst (RB) assay • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS) • a stimulating agent in Krebs-Ringer phosphate (KRP) medium • to induce thermal hyperalgesia in mice |
| Biochem/physiol Actions: | Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease. |
| Packaging: | 1, 5 g in poly bottle |
| Packaging: | 250 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |