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ZK 200775 hydrate

SIGMA/Z4777 - ≥98% (HPLC), powder

Synonym: Fanapanel; MPQX; [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-phosphonic acid hydrate

CAS Number: 1255517-78-2
Empirical Formula (Hill Notation): C14H15F3N3O6P · xH2O
Molecular Weight: 409.25 (anhydrous basis)
MDL Number: MFCD18452859
Linear Formula: C14H15F3N3O6P · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-Z4777-10MG 10 mg
 $216.00
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45-Z4777-50MG 50 mg
 $724.00
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assay ≥98% (HPLC)
color off-white to light brown
form powder
InChI 1S/C14H15F3N3O6P.H2O/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9;/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25);1H2
InChI key RYQLMFHPDNKPKY-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.OP(O)(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)N3CCOCC3)C(F)(F)F
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Z 200775 is a competetive AMPA/kainate receptor antagonist.
General description: ZK 200775 is a selective AMPA/kainite receptor antagonist with very low affinity for NMDA associated binding sites (Ki for CNQX binding site = 32 nM vs. 2.8 uM for DCKA binding site.) ZK 200775 displays superior PK and safety profiles in in vivo studies compared to quinoxalinedione antagonists such as NBQX, showing no effects on motor behavior or cardiac events at efficacious doses in rat. Additionally, unlike other quinoxalinediones, ZK 200775 is water soluble, making this a desirable tool compound for in vivo studies.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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