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Ampicillin

USP/1033000 - United States Pharmacopeia (USP) Reference Standard

Synonym: D-(−)-α-Aminobenzylpenicillin

CAS Number: 69-53-4
Empirical Formula (Hill Notation): C16H19N3O4S
Molecular Weight: 349.40
MDL Number: MFCD00005175
Linear Formula: C16H19N3O4S
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-1033000-200MG 200 mg
$436.00
1/EA
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API family ampicillin
application(s) pharmaceutical (small molecule)
description API family: ampicillin
format neat
grade pharmaceutical primary standard
InChI 1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1
InChI key AVKUERGKIZMTKX-NJBDSQKTSA-N
manufacturer/tradename USP
mp 208 °C (dec.) (lit.)
SMILES string [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3)C(O)=O
storage temp. 2-8°C
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Ampicillin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
• Ampicillin Sodium
• Ampicillin Capsules
• Ampicillin Tablets
• Ampicillin Boluses
• Ampicillin for Injection
• Ampicillin Soluble Powder
• Ampicillin for Oral Suspension
Biochem/physiol Actions: Mode of Action: Ampicillin is a semisynthetic penicillin and a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Effective against both Gram-positive (similar to benzylpenicillin) and Gram-negative bacteria (similar to tetracyclines and chloramphenicol.
Caution: This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Legal Information: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Preparation Note: Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.
mp 208 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 41116107

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