Synonym: 4′,5,7-Trihydroxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
CAS Number: 520-36-5
Empirical Formula (Hill Notation): C15H10O5
Molecular Weight: 270.24
MDL Number: MFCD00006831
Linear Formula: C15H10O5
Product Type: Chemical
| application(s) |
pharmaceutical (small molecule) |
| format |
neat |
| grade |
pharmaceutical primary standard |
| InChI |
1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
| InChI key |
KZNIFHPLKGYRTM-UHFFFAOYSA-N |
| manufacturer/tradename |
USP |
| mp |
>300 °C (lit.) |
| SMILES string |
Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 |
| storage temp. |
−20°C |
| Analysis Note: |
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: |
It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats. |
| Biochem/physiol Actions: |
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication. |
| General description: |
Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor. |
| Other Notes: |
Sales restrictions may apply. |
| Other Notes: |
USP issued SDS can be found here   . |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| mp |
>300 °C (lit.) |
| Storage Temp. |
−20°C |
| UNSPSC |
41116107 |
