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Bicalutamide

USP/1071202 - United States Pharmacopeia (USP) Reference Standard

Synonym: Bicalutamide (CDX); Casodex; Cosudex; N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

CAS Number: 90357-06-5
Empirical Formula (Hill Notation): C18H14F4N2O4S
Molecular Weight: 430.37
MDL Number: MFCD00869971
Linear Formula: C18H14F4N2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1071202-200MG 200 mg
 $436.00
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API family bicalutamide
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI key LKJPYSCBVHEWIU-UHFFFAOYSA-N
manufacturer/tradename USP
SMILES string CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
storage temp. 2-8°C
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Bicalutamide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biochem/physiol Actions: Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Storage Temp. 2-8°C
UNSPSC 41116107

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