Cefotaxime sodium

USP/1097909 - United States Pharmacopeia (USP) Reference Standard

Synonym: Cefotaxime sodium salt; Cefotaxim sodium salt

CAS Number: 64485-93-4
Empirical Formula (Hill Notation): C₁₆H₁₆N₅NaO₇S₂
Molecular Weight: 477.45
MDL Number: MFCD00079073
Linear Formula: C₁₆H₁₆N₅NaO₇S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-1097909-500MG	500 mg	$436.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	cefotaxime
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI key	AZZMGZXNTDTSME-JUZDKLSSSA-M
manufacturer/tradename	USP
SMILES string	[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)c3csc(N)n3)C([O-])=O
storage temp.	2-8°C

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Rapid evolutionary change in trait correlations of single proteins: This article explores the rapid evolutionary changes in protein traits, providing a fundamental understanding that can inform biochemical studies using tools like Cefotaxime sodium to influence protein interactions in bacterial cells, enhancing the effectiveness of antibacterial therapies (Dasmeh et al., 2024 ). Moringa oleifera as a potential antimicrobial against pathogenic Clostridium perfringens isolates in farm animals: Research investigates the antimicrobial properties of Moringa oleifera, with implications for enhancing the efficacy of antibiotic treatments like Cefotaxime sodium in combating bacterial infections in veterinary applications (Ibrahim and Altammar, 2024 ). In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study: This study examines the synergistic effects of Cefotaxime sodium with plant essential oils against E. coli, highlighting its potential in developing new antibacterial combinations that enhance drug efficacy and reduce resistance (Jain et al., 2024 ). Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis: This comprehensive review assesses the effectiveness of Cefotaxime sodium among other antibiotics in treating leptospirosis, offering critical insights into its clinical utility and safety profile (Ji et al., 2024 ). Changing Landscape of Antimicrobial Resistance in Neonatal Sepsis: An in silico Analyses of Multidrug Resistance in Klebsiella pneumoniae: The study discusses the rising challenge of antibiotic resistance, emphasizing the role of Cefotaxime sodium in treating complex cases of neonatal sepsis, thus underlining the need for continuous research into its mechanisms and resistance patterns (Vijayakumar et al., 2024 ).
Biochem/physiol Actions:	Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Broad spectrum third generation cephalosporin antibiotic.
Other Notes:	Sales restrictions may apply.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P284 - P304 + P340 - P342 + P311
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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