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Chloramphenicol

USP/1107004 - United States Pharmacopeia (USP) Reference Standard

Synonym: D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin

CAS Number: 56-75-7
Empirical Formula (Hill Notation): C11H12Cl2N2O5
Molecular Weight: 323.13
MDL Number: MFCD00078159
Linear Formula: Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1107004-200MG 200 mg
 $376.00
1/EA		 Add To Favorites

 

API family chloramphenicol
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key WIIZWVCIJKGZOK-RKDXNWHRSA-N
manufacturer/tradename USP
mp 149-153 °C (lit.)
SMILES string OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Chloramphenicol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
•  Chloramphenicol
•  Chloramphenicol Injection
•  Chloramphenicol Capsules
•  Chloramphenicol Tablets
•  Chloramphenicol Sodium Succinate
•  Chloramphenicol Ophthalmic Ointment
•  Chloramphenicol Compounded Oral Suspension, Veterinary
•  Chloramphenicol Sodium Succinate for Injection
Biochem/physiol Actions: Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Ph
Other Notes: Sales restrictions may apply.
mp 149-153 °C (lit.)
UNSPSC 41116107

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