Citric acid
USP/1134368 - United States Pharmacopeia (USP) Reference Standard
CAS Number: 77-92-9
Empirical Formula (Hill Notation): C6H8O7
Molecular Weight: 192.12
MDL Number: MFCD00011669
Linear Formula: HOC(COOH)(CH2COOH)2
Product Type: Chemical
| API family | citric acid |
| application(s) | USP Biologics pharmaceutical (small molecule) |
| expl. lim. | 8 %, 65 °F |
| form | crystalline |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C6H8O7/c7-3(8)1-6(13,5 |
| InChI key | KRKNYBCHXYNGOX-UHFFFAOYSA |
| manufacturer/tradename | USP |
| mp | 153-159 °C (lit.) |
| pKa | (1) 3.13, (2) 4.76, (3) 6.4 |
| SMILES string | OC(=O)CC(O)(CC(O)=O)C(O)= |
| solubility | water: 383 g/L at 25 °C |
| Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: | Citric acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as: • Anhydrous Citric Acid • Citric Acid Monohydrate • Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution • Monoglyceride Citrate • Powdered Garcinia Hydroxycitrate Extract • Anticoagulant Citrate Phosphate Dextrose Solution • Potassium Citrate Extended-Release Tablets |
| General description: | Citric acid is a weak organic acid naturally found in citrus fruits. It is widely used as an acidulant, preservative, and flavoring agent in the food and pharmaceutical industries. In pharmaceutical formulations, citric acid acts as a buffering agent to control pH and enhance the stability of active ingredients. The USP Citric Acid standard ensures the consistency and quality of citric acid used in these applications.The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics. |
| Other Notes: | Sales restrictions may apply. |
| Other Notes: | This product is part of USP Biologics Program. |
| Other Notes: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 153-159 °C (lit.) |
| UNSPSC | 41116107 |