Collagenase I

USP/1148089 - United States Pharmacopeia (USP) Reference Standard

Synonym: Collagenase from Clostridium histolyticum; Clostridiopeptidase A

CAS Number: 9001-12-1
MDL Number: MFCD00130830
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-1148089-2X0.5ML	0.5 mL	$555.00 1/EA	Add To Favorites

Sigma collagenases are fully characterized by enzymatic activity. Many are specifically tested for suitability for cell dissociation and cell viability for hepatocytes, adipocytes, and pancreatic cells.

Properties
Descriptions
Safety Info.
Basic Data

application(s)	USP Biologics pharmaceutical
form	liquid
format	neat
grade	pharmaceutical primary standard
manufacturer/tradename	USP

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Biochem/physiol Actions:	Collagenase is activated by four gram atom calcium per mole enzyme. It is inhibited by ethylene glycol-bis(beta-aminoethyl ether) - N, N, N′,N′-tetraacetic acid, beta-mercaptoethanol, glutathione, thioglycolic acid and 8-hydroxyquinoline.
General description:	Collagenase I is an enzyme that breaks down collagen, a primary structural protein in connective tissues. It is used in various medical and research applications, including tissue dissociation and wound debridement. The USP Collagenase I standard provides a benchmark for the activity and purity of collagenase I, ensuring its efficacy and safety in therapeutic and laboratory settings. The USP biologics proteins category provides critical standards and reference materials necessary for the development and manufacturing of therapeutic proteins. These proteins, which can be naturally derived or genetically engineered, are essential in treating various diseases and conditions, ensuring that they meet quality, safety, and efficacy standards. The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Other Notes:	One collagen digestion unit (CDU) liberates peptides from collagen from bovine achilles tendon equivalent in ninhydrin color to 1.0 μmole of leucine in 5 hours at pH 7.4 at 37 °C in the presence of calcium ions. One FALGPA hydrolysis unit hydrolyzes 1.0 μmole of furylacryloyl-Leu-Gly-Pro-Ala per min at 25°C. One Neutral Protease unit hydrolyzes casein to produce color equivalent to 1.0 μmole of tyrosine per 5 hr at pH 7.5 at 37°C. One Clostripain Unit hydrolyzes 1.0 μmole of BAEE per min at pH 7.6 at 25°C in the presence of DTT.
Other Notes:	Sales restrictions may apply.
Other Notes:	This product is part of the USP Biologics program.
Other Notes:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .

Symbol	GHS08
Signal word	Danger
Hazard statements	H334
Precautionary statements	P261 - P284 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Enzyme Commission (EC) Number	3.4.24.3 ( BRENDA \| IUBMB )
UNSPSC	41116107

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