Cyclosporine

USP/1158504 - United States Pharmacopeia (USP) Reference Standard

Synonym: Cyclosporin A; Antibiotic S 7481F1; Cyclosporine

CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight: 1202.61
MDL Number: MFCD00274558
Linear Formula: C₆₂H₁₁₁N₁₁O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-1158504-50MG	50 mg	$1530.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	cyclosporine
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N
manufacturer/tradename	USP
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
storage temp.	−20°C

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Cyclosporine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as: • Cyclosporine Capsules • Cyclosporine Injection • Cyclosporine Oral Solution • Cyclosporine Compounded Ophthalmic Solution, Veterinary
Biochem/physiol Actions:	A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Biochem/physiol Actions:	Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H350 - H360FD
Precautionary statements	P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Storage Temp.	−20°C
UNSPSC	41116107

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