Dexamethasone
USP/1176007 - United States Pharmacopeia (USP) Reference Standard
Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F
CAS Number: 50-02-2
Empirical Formula (Hill Notation): C22H29FO5
Molecular Weight: 392.46
MDL Number: MFCD00064136
Linear Formula: C22H29FO5
Product Type: Chemical
| agency | USP |
| API family | dexamethasone |
| application(s) | pharmaceutical (small molecule) |
| biological source | synthetic |
| color | white |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C22H29FO5/c1-12-8-16-1 |
| InChI key | UREBDLICKHMUKA-CXSFZGCWSA |
| manufacturer/tradename | USP |
| mp | 262-264 °C (lit.) |
| packaging | pkg of 125 mg |
| SMILES string | C[C@@H]1C[C@H]2[C@@H]3CCC |
| solubility | acetone: sparingly soluble |
| chloroform: slightly soluble | |
| ethanol: sparingly soluble | |
| ether: very slightly soluble | |
| methanol: sparingly soluble | |
| water: practically insoluble | |
| storage temp. | 2-8°C |
| vapor pressure | <0.0000001 kPa ( 25 °C) |
| Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: | Dexamethasone Related Compound J USP reference standard for use in specified quality tests and assays. Also used to prepare system suitability and standard solution during the performance test and impurity analysis by using liquid chromatography in conjunction with UV detector according to the given below monographs of United States Pharmacopeia (USP) : • Dexamethasone. • Dexamethasone Tablets. • Dexamethasone Oral Solution. • Dexamethasone Sodium Phosphate Ophthalmic Solution. |
| Application: | Dexamethasone USP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques. |
| Biochem/physiol Actions: | Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360FD |
| Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 262-264 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |