Erythromycin
USP/1242000 - United States Pharmacopeia (USP) Reference Standard
CAS Number: 114-07-8
Empirical Formula (Hill Notation): C37H67NO13
Molecular Weight: 733.93
MDL Number: MFCD00084654
Linear Formula: C37H67NO13
Product Type: Chemical
| API family | erythromycin |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C37H67NO13/c1-14-25-37 |
| InChI key | ULGZDMOVFRHVEP-RWJQBGPGSA |
| manufacturer/tradename | USP |
| SMILES string | CC[C@H]1OC(=O)[C@H](C)[C@ |
| storage temp. | −20°C |
| Application: | Erythromycin USP reference standard is used in specified quality tests and assays. It is also used to prepare the standard solution for spectroscopic identification tests, assays, and organic impurities analysis. It is also used in the preparation of standard solution as described in the United States Pharmacopeia (USP) monographs for identification, assay, and dissolution tests using thin-layer chromatography in: • Erythromycin Pledgets • Erythromycin Ophthalmic Ointment • Erythromycin Topical Solution • Erythromycin Delayed-Release Tablets Further information is available in the monograph chapter, Erythromycin, USP43-NF38 – 1683 of the USP (United States Pharmacopeia). |
| Biochem/physiol Actions: | Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex. Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria. |
| Caution: | This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C. |
| General description: | Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. Erythromycin, a bacteriostatic antibiotic, inhibits the growth of bacteria instead of killing them directly. It functions as a cytochrome P-450 inhibitor and is primarily excreted through bile. Erythromycin consists primarily of erythromycin A (C37H67NO13). The sum of the percentages of erythromycin A, erythromycin B, and erythromycin C is NLT 85.0% and NMT 100.5%, calculated on the anhydrous basis. Erythromycin demonstrates activity against both gram-positive and gram-negative bacteria, as well as other organisms. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. Erythromycin USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Legal Information: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia . |
| Other Notes: | This product is part of the USP Biologics program. |
| Preparation Note: | This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 41116107 |