Flecainide acetate

USP/1270800 - United States Pharmacopeia (USP) Reference Standard

Synonym: Flecainide acetate salt; N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt

CAS Number: 54143-56-5
Empirical Formula (Hill Notation): C₁₇H₂₀F₆N₂O₃ · C₂H₄O₂
Molecular Weight: 474.39
MDL Number: MFCD00214290
Linear Formula: C₁₇H₂₀F₆N₂O₃ · C₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-1270800-200MG	200 mg	$436.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	flecainide
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)
InChI key	RKXNZRPQSOPPRN-UHFFFAOYSA-N
manufacturer/tradename	USP
SMILES string	CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2
storage temp.	2-8°C

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Advanced Drug Delivery for Tuberculosis Treatment: Flecainide acetate is integral in developing inhalable porous particles, demonstrating effective lung drug delivery systems for treating tuberculosis. This novel application optimizes the therapeutic index of antituberculosis medications, minimizing systemic side effects while maximizing pulmonary uptake (Campos Pacheco et al., 2024 ). Cardiac Arrhythmia Management: Flecainide acetate, known for its role in arrhythmia management, has been studied for its efficacy following patent foramen ovale closure. The drug’s mechanism as a sodium channel inhibitor makes it a pivotal agent in preventing atrial fibrillation post-surgery, enhancing patient recovery and long-term cardiac health (Apostolos et al., 2024 ). Genetic Research on Arrhythmias: Flecainide acetate is used in genetic models to establish a life-threatening arrhythmia model by screening mutagenized mice. This research aids in identifying genetic predispositions to arrhythmias, paving the way for targeted therapies that modify disease progression and improve patient outcomes (Okabe et al., 2024 ). Electrophysiological Studies: Flecainide acetate′s properties as a class 1C antiarrhythmic agent are utilized in clinical electrophysiology to assess and refine therapeutic strategies for ventricular complex suppression in nonischemic cardiomyopathy. This application underlines its importance in detailed cardiac function studies and therapy optimization (Ruskin et al., 2024 ). Toxicology and Safety Profiling: Research on the potential pitfalls in using hypertonic sodium bicarbonate for treating cardiac toxic drug poisonings, where flecainide acetate is involved, underscores the complexity of managing drug-induced cardiac emergencies. This study provides crucial insights into safer, more effective antidotal therapies (Chan and Buckley, 2024 ).
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H315 - H319 - H335 - H360FD
Precautionary statements	P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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