Flurbiprofen
USP/1285750 - United States Pharmacopeia (USP) Reference Standard
Synonym: (±)-2-Fluoro-α-methyl-4-biphenylacetic acid; L-790,330
CAS Number: 5104-49-4
Empirical Formula (Hill Notation): C15H13FO2
Molecular Weight: 244.26
MDL Number: MFCD00079303
Linear Formula: C6H5C6H3(F)CH(CH3)CO2H
Product Type: Chemical
| API family | flurbiprofen |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C15H13FO2/c1-10(15(17) |
| InChI key | SYTBZMRGLBWNTM-UHFFFAOYSA |
| manufacturer/tradename | USP |
| mp | 110-112 °C (lit.) |
| SMILES string | CC(C(O)=O)c1ccc(c(F)c1)-c |
| Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: | Flurbiprofen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as: • Flurbiprofen Tablets • Flurbiprofen Sodium • Flurbiprofen Sodium Ophthalmic Solution |
| Biochem/physiol Actions: | Cyclooxygenase (COX) inhibitor; non-steroidal anti-inflammatory agent with antifungal activity. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity. |
| Biochem/physiol Actions: | Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P330 + P331 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 110-112 °C (lit.) |
| UNSPSC | 41116107 |