Gentamicin sulfate
USP/1289003 - United States Pharmacopeia (USP) Reference Standard
Synonym: Gentamicin sulfate salt; Gentamicin C complex sulfate.
CAS Number: 1405-41-0
EC Number: 215-778-9
MDL Number: MFCD00270181
Product Type: Chemical
API family | gentamicin |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C21H43N5O7.C20H41N5O7. |
InChI key | RDEIXVOBVLKYNT-HDZPSJEVSA |
manufacturer/tradename | USP |
SMILES string | O=S(O)(O)=O.O[C@]1(C)[C@@ |
Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: | Gentamicin sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as: • Gentamicin Sulfate Cream • Gentamicin Sulfate Ointment • Gentamicin Sulfate Ophthalmic Ointment • Gentamicin Sulfate Ophthalmic Solution • Gentamicin Sulfate and Betamethasone Valerate Topical Solution • Gentamicin Sulfate and Betamethasone Acetate Ophthalmic Solution • Gentamicin Sulfate and Betamethasone Valerate Otic Solution • Gentamicin and Prednisolone Acetate Ophthalmic Ointment |
Biochem/physiol Actions: | Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus. |
Caution: | Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142. |
General description: | Gentamicin Sulfate, consisting of sulfate salts, is a medication derived from antibiotic substances produced during the growth of Micromonospora purpurea bacterium. |
Legal Information: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia . |
Other Notes: | This product is part of the USP Biologics program. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H317 |
Precautionary statements | P280 - P302 + P352 |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 22-36/37-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
UNSPSC | 41116107 |