Isoniazid
USP/1349706 - United States Pharmacopeia (USP) Reference Standard
Synonym: 4-Pyridinecarboxylic acid hydrazide; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
CAS Number: 54-85-3
Empirical Formula (Hill Notation): C6H7N3O
Molecular Weight: 137.14
MDL Number: MFCD00006426
Linear Formula: C6H7N3O
Product Type: Chemical
API family | isoniazid |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C6H7N3O/c7-9-6(10)5-1- |
InChI key | QRXWMOHMRWLFEY-UHFFFAOYSA |
manufacturer/tradename | USP |
mp | 171-173 °C (lit.) |
SMILES string | NNC(=O)c1ccncc1 |
storage temp. | 2-8°C |
Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: | Isoniazid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
Biochem/physiol Actions: | Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia ![]() ![]() |
Other Notes: | Sales restrictions may apply. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H315 |
Precautionary statements | P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | 171-173 °C (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 41116107 |