Leuprolide acetate

USP/1358503 - United States Pharmacopeia (USP) Reference Standard

Synonym: Leuprolide acetate salt; des-Gly¹⁰-[D-Leu⁶]-LH-RH ethylamide; Leuprorelin

CAS Number: 74381-53-6
Empirical Formula (Hill Notation): C₅₉H₈₄N₁₆O₁₂ · xC₂H₄O₂
Molecular Weight: 1209.40 (free base basis)
MDL Number: MFCD00167544
Linear Formula: C₅₉H₈₄N₁₆O₁₂ · xC₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-1358503-1.97MG	1.97 mg	$1580.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	leuprolide
application(s)	USP Biologics pharmaceutical (small molecule)
form	powder
format	neat
grade	pharmaceutical primary standard
InChI	1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
InChI key	GFIJNRVAKGFPGQ-LIJARHBVSA-N
manufacturer/tradename	USP
SMILES string	CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
storage temp.	−20°C

Amino Acid Sequence:	Glp-His-Trp-Ser-Tyr-Leu-Leu-Arg-Pro-NHEt
Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Leuprolide Acetate USP reference standard is used to prepare standard solutions for the identification, assay, and determination of the purity of leuprolide acetate. Further information is available in monograph, Leuprolide Acetate, USP43-NF38 – 2572 of United States Pharmacopeia (USP).
General description:	Leuprolide acetate is a synthetic nonapeptide agonist of gonadotropin-releasing hormone (GnRH), used in the treatment of hormone-responsive cancers and reproductive disorders. It functions by downregulating pituitary gonadotropin secretion. The USP standard supports identity, potency, and impurity testing in peptide formulations. The USP biologics peptides category encompasses a diverse range of therapeutic peptides that are essential in managing various medical conditions. These peptides, typically consisting of amino acid sequences of 40 residues or less, are critical for the development of high-quality medicines. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of peptide therapeutics throughout their lifecycle. The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Other Notes:	Sales restrictions may apply.
Other Notes:	This product is part of the USP Biologics program.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	41116107

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