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Losartan potassium

USP/1370462 - United States Pharmacopeia (USP) Reference Standard

Synonym: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt; 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt; DuP 753; MK 954; Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide

CAS Number: 124750-99-8
Empirical Formula (Hill Notation): C22H22ClKN6O
Molecular Weight: 461.00
MDL Number: MFCD02092704
Linear Formula: C22H22ClKN6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1370462-150MG 150 mg
 $501.00
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API family losartan
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChI key OXCMYAYHXIHQOA-UHFFFAOYSA-N
manufacturer/tradename USP
SMILES string CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Losartan potassium USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
•  Losartan Potassium and Hydrochlorothiazide Tablets
•  Losartan Potassium Tablets
Biochem/physiol Actions: Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
Biochem/physiol Actions: orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist
General description: Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.
General description: Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.
Other Notes: Sales restrictions may apply.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 41116107

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