Synonym: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt; 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt; DuP 753; MK 954; Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
CAS Number: 124750-99-8
Empirical Formula (Hill Notation): C22H22ClKN6O
Molecular Weight: 461.00
MDL Number: MFCD02092704
Linear Formula: C22H22ClKN6O
Product Type: Chemical
| API family |
losartan |
| application(s) |
pharmaceutical (small molecule) |
| format |
neat |
| grade |
pharmaceutical primary standard |
| InChI |
1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1 |
| InChI key |
OXCMYAYHXIHQOA-UHFFFAOYSA-N |
| manufacturer/tradename |
USP |
| SMILES string |
CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K] |
| Analysis Note: |
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: |
Losartan potassium was used as reference standard for determination of Losartan and metabolite in rat urine samples using HPLC coupled with fluorescence detector. |
| Biochem/physiol Actions: |
Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension. |
| General description: |
Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist. |
| General description: |
Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension. |
| Other Notes: |
Sales restrictions may apply. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
