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Methoxsalen

USP/1417001 - United States Pharmacopeia (USP) Reference Standard

Synonym: 8-Methoxypsoralen; 8-MOP; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; Ammoidin; Methoxsalen; Xanthotoxin

CAS Number: 298-81-7
Empirical Formula (Hill Notation): C12H8O4
Molecular Weight: 216.19
MDL Number: MFCD00005009
Linear Formula: C12H8O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1417001-200MG 200 mg
 $436.00
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API family methoxsalen
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChI key QXKHYNVANLEOEG-UHFFFAOYSA-N
manufacturer/tradename USP
mp 148-150 °C (lit.)
SMILES string COc1c2OC(=O)C=Cc2cc3ccoc13
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Biochem/physiol Actions: 8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302 - H317
Precautionary statements P280 - P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
mp 148-150 °C (lit.)
UNSPSC 41116107

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