Miconazole nitrate
USP/1443500 - United States Pharmacopeia (USP) Reference Standard
Synonym: (±)-Miconazole nitrate salt; 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
CAS Number: 22832-87-7
Empirical Formula (Hill Notation): C18H14Cl4N2O · HNO3
Molecular Weight: 479.14
MDL Number: MFCD00058161
Linear Formula: C18H14Cl4N2O · HNO3
Product Type: Chemical
API family | miconazole |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C18H14Cl4N2O.HNO3/c19- |
InChI key | MCCACAIVAXEFAL-UHFFFAOYSA |
manufacturer/tradename | USP |
SMILES string | ClC1=CC(Cl)=CC=C1C(OCC2=C |
Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: | Miconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
Biochem/physiol Actions: | Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis. |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia . |
Other Notes: | Sales restrictions may apply. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 - H317 |
Precautionary statements | P280 - P301 + P312 + P330 - P302 + P352 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
UNSPSC | 41116107 |