Synonym: Mitoxantrone dihydrochloride; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
CAS Number: 70476-82-3
Empirical Formula (Hill Notation): C22H28N4O6 · 2HCl
Molecular Weight: 517.40
MDL Number: MFCD00242943
Linear Formula: C22H28N4O6 · 2HCl
Product Type: Chemical
API family |
mitoxantrone |
application(s) |
pharmaceutical (small molecule) |
format |
neat |
grade |
pharmaceutical primary standard |
InChI |
1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H |
InChI key |
ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
manufacturer/tradename |
USP |
SMILES string |
Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 |
Analysis Note: |
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: |
Mitoxantrone hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
Biochem/physiol Actions: |
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis. |
General description: |
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia ![External link](https://krackeler.com/images/sigma/ext-link.gif) . |
Other Notes: |
Sales restrictions may apply. |
Symbol |
GHS08 |
Signal word |
Danger |
Hazard statements |
H340 - H360 |
Precautionary statements |
P201 - P280 - P308 + P313 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |