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Nebivolol hydrochloride

USP/1457833 - United States Pharmacopeia (USP) Reference Standard

Synonym: Narbivolol; Nebilet; R-65824; rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

CAS Number: 152520-56-4
Empirical Formula (Hill Notation): C22H25F2NO4 · HCl
Molecular Weight: 441.90
MDL Number: MFCD28168034
Linear Formula: C22H25F2NO4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1457833-150MG 150 mg
 $2390.00
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API family nebivolol
application(s) pharmaceutical
format neat
grade pharmaceutical primary standard
InChI 1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1
InChI key JWEXHQAEWHKGCW-BIISKSHESA-N
manufacturer/tradename USP
SMILES string Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3
storage temp. 2-8°C
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Nebivolol hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biochem/physiol Actions: Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension.
Biochem/physiol Actions: Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Storage Temp. 2-8°C
UNSPSC 41116107

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