Neomycin sulfate

USP/1458009 - United States Pharmacopeia (USP) Reference Standard

Synonym: Neomycin trisulfate salt; Neomycin B sulfate

CAS Number: 1405-10-3
Empirical Formula (Hill Notation): C₂₃H₄₆N₆O₁₃ · 3H₂SO₄
Molecular Weight: 908.88
MDL Number: MFCD00037007
Linear Formula: C₂₃H₄₆N₆O₁₃ · 3H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-1458009-200MG	200 mg	$511.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	neomycin
application(s)	USP Biologics pharmaceutical (small molecule)
form	solid
format	neat
grade	pharmaceutical primary standard
InChI	1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1
InChI key	OIXVKQDWLFHVGR-GQTDVWSESA-N
manufacturer/tradename	USP
SMILES string	[S](=O)(=O)(O)O.N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CN)O[C@H]2[C@@H]([C@H]([C@@H](C[C@@H]2N)N)O)O[C@@H]3O[C@@H]([C@H]([C@H]3O)OC4O[C@H]([C@H]([C@@H]([C@H]4N)O)O)CN)CO

Application:	Neomycin sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as: • Neomycin Sulfate Tablets • Neomycin Sulfate Cream • Neomycin Sulfate Ointment • Neomycin Sulfate Ophthalmic Ointment • Neomycin Sulfate Oral Solution • Neomycin Sulfate and Hydrocortisone Cream
Disclaimer:	Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
General description:	Neomycin sulfate is a complex aminoglycoside antibiotic comprising multiple neomycin components. It is active against Gram-negative bacteria and inhibits protein synthesis by binding to the 30S ribosomal subunit. The USP standard supports microbiological potency assays and chromatographic analysis of bulk and finished products. The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle. The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Legal Information:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	This product is part of the USP Biologics program.
Preparation Note:	Neomycin sulfate is soluble in H₂O at 50 mg/mL, yielding a clear solution.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P284 - P304 + P340 - P342 + P311
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

41116107

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