Neomycin sulfate

USP/1458009 - United States Pharmacopeia (USP) Reference Standard

Synonym: Neomycin trisulfate salt; Neomycin B sulfate

CAS Number: 1405-10-3
Empirical Formula (Hill Notation): C₂₃H₄₆N₆O₁₃ · 3H₂SO₄
Molecular Weight: 908.88
Linear Formula: C₂₃H₄₆N₆O₁₃ · 3H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-1458009-200MG	200 mg	$447.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	neomycin
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1
InChI key	OIXVKQDWLFHVGR-GQTDVWSESA-N
manufacturer/tradename	USP

Application:	Neomycin sulfate USP reference standard intended for use in specified quality tests and assays. It is also used to prepare sample solution for assay of Polymyxin B according to the given below monographs of United States Pharmacopeia (USP):• Neomycin and Polymyxin B Sulfates and Hydrocortisone Ophthalmic Suspension • Neomycin and Polymyxin B Sulfates Ophthalmic Ointment • Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Lidocaine Ointment • Neomycin and Polymyxin B Sulfates and Lidocaine Cream • Neomycin Sulfate and Hydrocortisone Otic Suspension • Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Further information is available in the monograph, Neomycin Sulfate, USP43-NF38 - 3120, USP43-NF38 - 3126, etc of the USP (United States Pharmacopeia).
Caution:	Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
General description:	Neomycin Sulfate is the sulfate salt of a kind of neomycin, an antibacterial substance produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae), or a mixture of two or more such salts, the main component being neomycin B sulfate. It has a potency equivalent to NLT 600 µg of neomycin/mg, calculated on the dried basis. Neomycin sulfate USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Legal Information:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	This product is part of the USP Biologics program.
Preparation Note:	Neomycin sulfate is soluble in H₂O at 50 mg/mL, yielding a clear solution.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P284 - P304 + P340 - P342 + P311
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

41116107

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