Proguanil hydrochloride
USP/1568040 - United States Pharmacopeia (USP) Reference Standard
Synonym: Chlorguanide; N1-(4-Chlorophenyl)-N5-isopropylbiguanide
CAS Number: 637-32-1
Empirical Formula (Hill Notation): C11H16ClN5·HCl
Molecular Weight: 290.19
MDL Number: MFCD01732193
Linear Formula: C11H16ClN5·HCl
Product Type: Chemical
API family | proguanil |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C11H16ClN5.ClH/c1-7(2) |
InChI key | SARMGXPVOFNNNG-UHFFFAOYSA |
manufacturer/tradename | USP |
SMILES string | Cl.CC(C)NC(=N)NC(=N)Nc1cc |
Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: | Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
Biochem/physiol Actions: | Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia ![]() ![]() |
Other Notes: | Sales restrictions may apply. |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P330 + P331 + P310 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
UNSPSC | 41116107 |