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Quinine sulfate

USP/1597005 - United States Pharmacopeia (USP) Reference Standard

Synonym: Quinine hemisulfate salt monohydrate; Quinine sulfate (2:1) (salt) dihydrate

CAS Number: 207671-44-1
Empirical Formula (Hill Notation): C20H24N2O2 · 0.5H2O4S · H2O
Molecular Weight: 391.47
MDL Number: MFCD00150790
Linear Formula: C20H24N2O2 · 0.5H2O4S · H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1597005-500MG 500 mg
 $436.00
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API family quinine
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
InChI key ZHNFLHYOFXQIOW-LPYZJUEESA-N
manufacturer/tradename USP
mol wt monograph mol wt. 782.94 ((C20H24N2O2)2 . H2SO4 . 2H2O)
mp ~225 °C (dec.) (lit.)
SMILES string O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Quinine sulfate may be used as a pharmaceutical primary standard for the quantification of the analyte in pharmaceutical formulations using chromatography techniques.
Biochem/physiol Actions: Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .

Quinine sulfate is the sulfate salt of quinine, an alkaloid, obtained from the bark of Cinchona species.
Other Notes: Sales restrictions may apply.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
mp ~225 °C (dec.) (lit.)
UNSPSC 41116107

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