Simvastatin

USP/1612700 - United States Pharmacopeia (USP) Reference Standard

CAS Number: 79902-63-9
Empirical Formula (Hill Notation): C₂₅H₃₈O₅
Molecular Weight: 418.57
MDL Number: MFCD00072007
Linear Formula: C₂₅H₃₈O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-1612700-200MG	200 mg	$436.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	simvastatin
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChI key	RYMZZMVNJRMUDD-HGQWONQESA-N
manufacturer/tradename	USP
mp	127-132 °C (lit.)
SMILES string	[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Simvastatin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biochem/physiol Actions:	Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147).
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.

Symbol	GHS08
Signal word	Warning
Hazard statements	H361d
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	127-132 °C (lit.)
UNSPSC	41116107

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