Simvastatin
USP/1612700 - United States Pharmacopeia (USP) Reference Standard
CAS Number: 79902-63-9
Empirical Formula (Hill Notation): C25H38O5
Molecular Weight: 418.57
MDL Number: MFCD00072007
Linear Formula: C25H38O5
Product Type: Chemical
API family | simvastatin |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C25H38O5/c1-6-25(4,5)2 |
InChI key | RYMZZMVNJRMUDD-HGQWONQESA |
manufacturer/tradename | USP |
mp | 127-132 °C (lit.) |
SMILES string | [H][C@]12[C@H](C[C@@H](C) |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
Application: | Simvastatin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
Biochem/physiol Actions: | Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147). |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia ![]() ![]() |
Other Notes: | Sales restrictions may apply. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H361d |
Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 127-132 °C (lit.) |
UNSPSC | 41116107 |