Tacrolimus

USP/1642802 - United States Pharmacopeia (USP) Reference Standard

Synonym: FK-506 monohydrate; Tacrolimus

CAS Number: 109581-93-3
Empirical Formula (Hill Notation): C₄₄H₆₉NO₁₂ · H₂O
Molecular Weight: 822.03
MDL Number: MFCD11045918
Linear Formula: C₄₄H₆₉NO₁₂ · H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-1642802-100MG	100 mg	$1830.00 1/EA		Add To Favorites
45-1642802-150MG	150 mg	$1590.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	tacrolimus
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
InChI key	NWJQLQGQZSIBAF-MLAUYUEBSA-N
manufacturer/tradename	USP
SMILES string	O.CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)CC(C)=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC

Analysis Note:	These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application:	Tacrolimus USP reference standard is intended for use in specified quality tests and assays as per USP compendia. Also used to prepare standard and system suitability solutions for assay, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP): • Tacrolimus • Tacrolimus Capsules • Tacrolimus Compounded Oral Suspension
Biochem/physiol Actions:	FK-506 is a potent immunosuppressant, neuroprotective and neuroregenerative, and in vitro T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P330 + P331 + P310
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

41116107

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