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Tretinoin

USP/1674004 - United States Pharmacopeia (USP) Reference Standard

Synonym: Retinoic acid; ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid

CAS Number: 302-79-4
Empirical Formula (Hill Notation): C20H28O2
Molecular Weight: 300.44
MDL Number: MFCD00001551
Linear Formula: C20H28O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1674004-5X30MG 30 mg
 $467.00
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API family tretinoin
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key SHGAZHPCJJPHSC-YCNIQYBTSA-N
manufacturer/tradename USP
mp 180-181 °C (lit.)
SMILES string CC1=C(C=CC(C)=CC=CC(C)=CC(O)=O)C(C)(C)CCC1
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Tretinoin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
•  Tretinoin Cream
•  Tretinoin Gel
•  Tretinoin Topical Solution
•  Isotretinoin
•  Isotretinoin Capsules
•  Acitretin
Biochem/physiol Actions: all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Biochem/physiol Actions: Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR); primes embryonic stem cells to become neurons.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
mp 180-181 °C (lit.)
UNSPSC 41116107

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