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Zoledronic acid

USP/1724827 - United States Pharmacopeia (USP) Reference Standard

Synonym: Zoledronic acid monohydrate; P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate

CAS Number: 165800-06-6
Empirical Formula (Hill Notation): C5H10N2O7P2·H2O
Molecular Weight: 290.10
MDL Number: MFCD08448695
Linear Formula: C5H10N2O7P2·H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1724827-150MG 150 mg
 $436.00
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API family zoledronic acid
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key FUXFIVRTGHOMSO-UHFFFAOYSA-N
manufacturer/tradename USP
SMILES string O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Zoledronic acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biochem/physiol Actions: Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 41116107

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