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Astec® CHIROBIOTIC® V Chiral HPLC Column

SUPELCO/11023AST - 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Synonym: Vancomycin Chiral Column

Product Type: Equipment/Book

Catalog Number PKG Qty. Price Quantity
45-11023AST 1 ea
$2400.00
1/EA
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agency suitable for USP L88
description HPLC Column
L × I.D. 15 cm × 4.6 mm
manufacturer/tradename Astec®
material stainless steel column
matrix High-purity silica gel particle platform
  fully porous particle
matrix active group vancomycin phase
packaging pkg of 1 ea
parameter 0-45 °C temperature
  80-110 bar pressure (1200-1500 psi)
particle size 5 μm
pH range 3.5-7.0
pore size 100 Å
product line Astec®
Quality Level 100 
separation technique chiral
technique(s) HPLC: suitable
  LC/MS: suitable
Application:


  • Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study highlights the application of UFLC-MS/MS combined with Astec® CHIROBIOTIC® V Chiral HPLC Column for the enantioselective analysis of various therapeutic agents in rat plasma, providing a crucial methodological advancement for pharmacokinetic research ( Zhang et al., 2016 ).


General description: Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

• Bonded phase: Vancomycin
• Operating pH range: 3.5 - 7.0
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
Legal Information: Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
Legal Information: CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Recommended products: Discover LiChropur reagents ideal for HPLC  or LC-MS  analysis
UNSPSC 41115700

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