Astec^® CHIROBIOTIC^® T Chiral HPLC Column

SUPELCO/12022AST - 5 μm particle size, L × I.D. 10 cm × 4.6 mm

Synonym: CHIROBIOTIC T Chiral Chromatography Column

Product Type: Equipment/Book

Catalog Number	PKG Qty.	Price	Quantity


45-12022AST	1 ea	$2070.00 1/EA		Add To Favorites

Properties
Descriptions
Basic Data

agency	suitable for USP L63
description	HPLC column
L × I.D.	10 cm × 4.6 mm
manufacturer/tradename	Astec^®
material	stainless steel column
matrix	High-purity silica gel particle platform
	fully porous particle
matrix active group	teicoplanin glycopeptide phase
operating pH range	3.8-6.8
packaging	pkg of 1 ea
parameter	0-45 °C temperature
	241 bar pressure (3500 psi)
particle size	5 μm
pore size	100 Å
product line	Astec^®
Quality Level	100
separation technique	chiral
technique(s)	HPLC: suitable
	LC/MS: suitable

Application:	Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.: This study utilizes the Astec CHIROBIOTIC T Chiral HPLC Column to develop an LC-MS/MS method for detecting and quantifying salbutamol enantiomers in urine samples. This application demonstrates the column′s utility in biomedical and clinical research, particularly in the analysis of chiral drugs in biological matrices (Chan et al., 2016 ). High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research focuses on the enantioseparation of various amino acids using the Astec CHIROBIOTIC T Chiral HPLC Column, highlighting its effectiveness in separating complex chiral molecules. The study underscores the column′s application in the enantioselective analysis of amino acids and related compounds in chemical and pharmaceutical research (Berkecz et al., 2009 ).
General description:	CHIROBIOTIC^® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC^® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC^® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity. • Bonded phase: Teicoplanin • Operating pH range: 3.8 - 6.8 • Particle diameter: 5, 10 or 16 μm • Pore size: 100 Å (CHIROBIOTIC^® T) or 200 Å (CHIROBIOTIC^® T2) CHIROBIOTIC FAQs CHIROBIOTIC Reference Bibliography Chiral Product Literature
Legal Information:	Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
Legal Information:	CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Recommended products:	Discover LiChropur reagents ideal for HPLC or LC-MS analysis

UNSPSC

41115700

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