Astec^® CHIROBIOTIC^® V2 Chiral HPLC Column

SUPELCO/15024AST - 5 μm particle size, L × I.D. 25 cm × 4.6 mm

Synonym: Chirobiotic V2 TM=["Astec"] Chromatography Column

Product Type: Equipment/Book

Catalog Number	PKG Qty.	Price	Quantity


45-15024AST	1 ea	$2840.00 1/EA		Add To Favorites

Properties
Descriptions
Basic Data

agency	suitable for USP L88
description	HPLC column
L × I.D.	25 cm × 4.6 mm
manufacturer/tradename	Astec^®
material	stainless steel column
matrix	High-purity silica gel particle platform
	fully porous particle
matrix active group	vancomycin phase
operating pH range	3.5-7.0
packaging	pkg of 1 ea
parameter	0-45 °C temperature
	241 bar pressure (3500 psi)
particle size	5 μm
pore size	200 Å
product line	Astec^®
Quality Level	100
separation technique	chiral
technique(s)	HPLC: suitable
	LC/MS: suitable

Application:	Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC^® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022 ). Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC^® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016 ). New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC^® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009 ).
General description:	Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC^® V in the polar ionic mode. The CHIROBIOTIC^® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC^® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity. • Bonded phase: Vancomycin • Operating pH range: 3.5 - 7.0 • Particle diameter: 5, 10 or 16 μm • Pore size: 100 Å (CHIROBIOTIC^® V) or 200 Å (CHIROBIOTIC^® V2) CHIROBIOTIC FAQs CHIROBIOTIC Reference Bibliography Chiral Product Literature
Legal Information:	Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
Legal Information:	CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Recommended products:	Discover LiChropur reagents ideal for HPLC or LC-MS analysis

UNSPSC

41115700

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