N-Nitrosodiethylamine (NDEA) solution
SUPELCO/40334 - certified reference material, 5000 μg/mL in methanol
Synonym: Diethylnitrosamine
CAS Number: 55-18-5
MDL Number: MFCD00013890
Product Type: Chemical
| application(s) | cleaning products cosmetics environmental food and beverages personal care |
| CofA | current certificate can be downloaded |
| concentration | 5000 μg/mL in methanol |
| format | single component solution |
| grade | TraceCERT® |
| certified reference material | |
| InChI | 1S/C4H10N2O/c1-3-6(4-2)5- |
| InChI key | WBNQDOYYEUMPFS-UHFFFAOYSA |
| packaging | ampule of 1 mL |
| product line | TraceCERT® |
| Quality Level | 100  |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | The CRM can be used as follows:• Simultaneous analysis of N-nitrosodiethanolamine, N-nitrosodiethylamine, triethanolamine, diethanolamine in cosmetic samples using liquid chromatography-electrospr • Solid phase extraction of N-nitrosodimethylamine and N-nitrosomethylethylamine from eight sartans, ranitidine, and metformin and also the fortified products of these drugs, for quantification by gas chromatography-tandem mass spectrometry (GC-MS/MS) • Multi-residue analysis of seven restricted nitrosamines in two body creams and two shower gel samples by vortex-assisted reversed-phase dispersive liquid-liquid microextraction (VA-RP-DLLME) and liquid chromatography-mass spectrometry (LC-MS) • Quantitative analysis of four nitrosamines in four sartan drug substances— candesartan cilexetil, olmesartan medoxomi, irbesartan, and valsartan, by gas chromatography-tandem mass spectrometry (GC-MS/MS) • Determination of eight volatile nitrosamines in 28 popular meat product samples using ultrasonic solvent extraction combined with solid phase microextraction (SPME) and GC-MS |
| General description: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. N-Nitrosodiethylamine belongs to the group of toxic nitrosamines, known to show carcinogenic, mutagenic, and hepatotoxic properties. It is formed as a byproduct during food processing, pharmaceutical processing, and water treatment. As a result, they are generally found in water, fish, meat, drug substances, etc. |
| Legal Information: | TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Symbol |    GHS02,GHS06,GHS08,GHS02,GHS06,GHS08 |
| Signal word | Danger-Danger |
| Hazard statements | H225 - H301 + H311 + H331 - H350 - H370 - H225 - H301 + H311 + H331 - H350 - H370 |
| Precautionary statements | P201 - P210 - P280 - P202 - P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 - P301 |
| Hazard Codes | T |
| Risk Statements | 45-23/24/25-39/23/24/25 |
| Safety Statements | 53-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | WGK 3 |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116105 |