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LiChrospher® RP-18 HPLC Column

SUPELCO/50137-U - 5 μm particle size, L × I.D. 25 cm × 4 mm

Synonym: TM=["LiChrospher"] C18 HPLC column

Product Type: Equipment/Book
Catalog Number PKG Qty. Price Quantity
45-50137-U 1 ea
 $950.00
1/EA		 Add To Favorites
agency suitable for USP L1
application(s) food and beverages
extent of labeling 21% Carbon loading
feature endcapped: no
L × I.D. 25 cm × 4 mm
manufacturer/tradename LiChrospher®
material stainless steel column
matrix octadecyl
  silica particle platform
  fully porous particle
matrix active group C18 (octadecyl) phase
operating pH 2-7.5
packaging 1 ea of
parameter ≤70 °C temp. range
  400 bar pressure (5801 psi)
particle size 5 μm
pore size 100 Å
product line LiChrospher®
Quality Level 100 
separation technique reversed phase
surface area 350 m2/g
technique(s) HPLC: suitable
Application:

  • HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia.: This study developed and validated HPLC-UV and GC-MS methods for determining chlorambucil and valproic acid in plasma, aiming to explore their combined therapy for chronic lymphocytic leukemia. The LiChrospher® RP-18 HPLC Column was instrumental in achieving the separation and quantification (Lipska et al., 2021 ).

  • Rapid Determination of Metronidazole and 2-Hydroxymetronidazole in Murine Blood Plasma.: This research utilized the LiChrospher® RP-18 HPLC Column for the rapid determination of metronidazole and its metabolite in murine blood plasma, highlighting its effectiveness in pharmacokinetic studies (Zemanová et al., 2022 ).

  • Application of chemometric approach for development and validation of high performance liquid chromatography method for estimation of ropinirole hydrochloride.: This paper presents a chemometric approach to developing and validating an HPLC method for estimating ropinirole hydrochloride, utilizing the LiChrospher® RP-18 column for precise and accurate results (Fatima et al., 2019 ).

  • A New Solid-Phase Extraction Method for Determination of Pantoprazole in Human Plasma Using High-Performance Liquid Chromatography.: The study developed a novel solid-phase extraction method for determining pantoprazole in human plasma using HPLC with the LiChrospher® RP-18 column, achieving high sensitivity and specificity (Zendelovska et al., 2019 ).

  • Application of an HPLC-MS/MS method for Teicoplanin drug substance and related impurities, part 2: Identity assignment of related impurities.: This research employed the LiChrospher® RP-18 column in an HPLC-MS/MS method to identify and assign related impurities in teicoplanin drug substances, demonstrating the column′s capability in impurity profiling (Tengattini et al., 2019 ).
General description: LiChrospher® RP-18 HPLC column (L × I.D. 25 cm × 4 mm) is found to be reliable and high versatile. Suitable for reversed-phase high performance liquid chromatography (RP-HPLC) of acidic, neutral and weakly basic compounds, according to L1 USP specifications.
Legal Information: LiChrospher is a registered trademark of Merck KGaA, Darmstadt, Germany
Recommended products: Discover LiChropur reagents ideal for HPLC  or LC-MS  analysis
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 41115700

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