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Discovery® C18 HPLC Column

SUPELCO/504971-40 - 5 μm particle size, L × I.D. 25 cm × 4 mm

Synonym: C18 TM=["Discovery"] HPLC Column

Product Type: Equipment/Book
Catalog Number PKG Qty. Price Quantity
45-504971-40 1 ea
 $996.00
1/EA		 Add To Favorites

 

agency suitable for USP L1
application(s) food and beverages
extent of labeling 12% Carbon loading
feature endcapped
impurities <10 ppm metals
L × I.D. 25 cm × 4 mm
manufacturer/tradename Discovery®
material stainless steel column
matrix silica gel, high purity, spherical particle platform
  fully porous particle
matrix active group C18 (octadecyl) phase
operating pH range 2-8
packaging 1 ea of
parameter ≤70 °C temp. range
  400 bar pressure (5801 psi)
particle size 5 μm
pore size 180 Å
product line Discovery®
Quality Level 100 
separation technique reversed phase
surface area 300 m2/g
surface coverage 3 μmol/m2
technique(s) HPLC: suitable
  LC/MS: suitable
Application:

  • Identification, isolation and characterization of dolutegravir forced degradation products and their cytotoxicity potential.: Utilizes the Discovery® C18 HPLC Column to study the stability and degradation of the antiretroviral drug dolutegravir, crucial for ensuring drug safety and efficacy (Saida et al., 2019 ).

  • Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid beta 1-42.: This methodological study leverages the Discovery® C18 HPLC Column for the purification and analysis of amyloid beta peptides, contributing to research on Alzheimer′s disease (Prakash et al., 2019 ).

  • Development and validation of a HPLC electrochemical detection method to measure COMT activity as a tool in drug development.: Showcases the use of the Discovery® C18 HPLC Column in developing a novel analytical method for measuring catechol-O-methyltransferase (COMT) activity, instrumental in the development of psychiatric and neurological medications (Viljoen et al., 2019 ).
Features and Benefits: • Excellent reproducibility
• Exceptional peak shape for basic and acidic analytes
• Stable, low-bleed LC-MS separations
• Separation of peptides and small proteins
• Lower hydrophobicity than many comparable C18 columns, providing faster analysis
General description: Use Discovery® C18 for any method that specifies a C18. The exceptional peak shape, reproducibility, and stability make it the column of choice for all C18 methods from demanding to routine.
Legal Information: Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Recommended products: Discover LiChropur reagents ideal for HPLC  or LC-MS  analysis
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 41115700

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