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Discovery® HS C18 HPLC Column

SUPELCO/569253-U - 3 μm particle size, L × I.D. 5 cm × 2.1 mm

Synonym: Discovery RP18 HPLC Column

Product Type: Equipment/Book
Catalog Number PKG Qty. Price Quantity
45-569253-U 1 ea
 $697.00
1/EA		 Add To Favorites
agency suitable for USP L1
application(s) food and beverages
extent of labeling 20% Carbon loading
feature endcapped
impurities <10 ppm metals
L × I.D. 5 cm × 2.1 mm
manufacturer/tradename Discovery®
material stainless steel column
matrix silica gel, high purity, spherical particle platform
  fully porous particle
matrix active group C18 (octadecyl) phase
operating pH range 2-8
packaging 1 ea of
parameter ≤70 °C temp. range
  400 bar pressure (5801 psi)
particle size 3 μm
pore size 120 Å
product line Discovery®
Quality Level 100 
separation technique reversed phase
surface area 300 m2/g
surface coverage 3.2 μmol/m2
technique(s) HPLC: suitable
  LC/MS: suitable
Application:

  • Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024 ).

  • A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022 ).

  • Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020 ).
Features and Benefits: • Stable, low bleed for LC-MS applications
• Scalable from analytical to preparatory
• Highly stable to ensure excellent run-to-run and lot-to-lot reproducibility
• Higher hydrophobicity for better resolution of difficult analytes
   
General description: Discovery® HS C18 HPLC column (L × I.D. 5 cm × 2.1 mm) is commonly found to be stable under acidic and basic conditions.
Legal Information: Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Recommended products: Discover LiChropur reagents ideal for HPLC  or LC-MS  analysis
UNSPSC 41115700

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